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In the paper problems which seems to be significant and unavoidable for CELSS practical application are considered: 1) the problem of selection of appropriate CELSS composition, which is highly important for concentrating efforts and finance on the most promising version of CELSS; 2) the problem of comprehensive testing of CELSS and evaluating its reliability which is obligatory necessary for real applications; 3) the problem of reproducing and comparing different experimental data from different CELSS. Possible ways of solving this problems are considered.

Of the possible Life Support Systems evaluation criteria, the criterion of "integral reliability" is proposed. This criterion incorporates three main indices: reliability, mass, and quality of life. It is possible to interrelate these indices only if the space mission is considered as a whole. It is shown that there must exist a LSS mass optimum with respect to mission reliability. The specific form of "integral reliability" expression and the number of terms depend on the mission scenario. This work considers different LSS for orbital station, Lunar base, and Mars mission scenarios.