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Crash-involved motorcycle riders, even if they are wearing helmets, face a high injury risk, frequently associated with long-term or permanent disability. The effectiveness of protective garments, such as leather clothing, heavy boots etc., in terms of reducing the duration of hospitalization, disability to work and school, and the incidence of permanent physical defects is subject of this paper. A prospective study carried out in the Greater Munich Area indicates that for injured motorcyclists wearing motorcycle clothing, on average, the duration of hospitalization is diminished by 7 days, disability to work and school by 20 days, and the incidence of permanent physical defects as a consequence of the sustained injuries is reduced by 40%, compared to riders not wearing motorcycle clothing.