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No regional or directional large-deformation constitutive data for brain exist in the current literature. To address this deficiency, the large strain (up to 50%) directional properties of gray and white matter were determined in the thalamus, corona radiata, and corpus callosum. The constitutive relationships of all regions and directions are well fit by an Ogden hyperelastic relationship, modified to include dissipation. The material parameter α, representing the non-linearity of the tissue, was not significantly sensitive to region, direction, or species. The average value of the material parameter µ, corresponding to the shear modulus of the tissue, was significantly different for each region, demonstrating that brain tissue is inhomogeneous. In each region, µ, obtained in 2 orthogonal directions, was compared. Consistent with local neuroarchitecture, gray matter showed the least amount of anisotropy and corpus callosum exhibited the greatest degree of anisotropy.

There is a paucity of data regarding the potential for pediatric cervical spine injury as a result of acceleration of the head with no direct impact during automotive crashes. Sled tests were conducted using a 3-year-old anthropomorphic test device (ATD) to investigate the effect of restraint type and crash severity on the risk of pediatric inertial neck injury. At higher crash severities, the ATD restrained by only the vehicle three-point restraints sustained higher peak neck tension, peak neck extension and flexion moments, neck injury criterion (Nij) values, peak head accelerations, and HIC values compared to using a forward-facing child restraint system (CRS). The injury assessment reference values (IARVs) for peak tension and Nij were exceeded in all 48 and 64 kph delta-V tests using any restraint type.

Over half of the 1.2 million annual traffic fatalities worldwide are pedestrians struck by motor vehicles [ 1 ]. Medical databases, such as the National Inpatient Sample (NIS), have been utilized to ascertain injury patterns in the general population of injured pedestrians [ 2 - 3 ]. However, the authors are not aware of any studies investigating how factors, such as physical impairments, intoxication, and pre-existing medical implants (e.g. hip replacement, artificial knee, etc.) affect the prevalence of pedestrian accidents or injury outcomes. Five to eight million inpatient hospitalization records are included in the NIS annually, and this large sample size allows for analyses that are not possible with smaller data sets on pedestrian injuries. The current study utilizes the NIS to evaluate how several factors such as blindness, deafness, intoxication, and pre-existing medical implants affect injury patterns when compared to the general population of hospitalized pedestrians.

Neck injury assessment reference values (IARVs) and tolerance values for children have been specified using animal data compared to the loading of anthropomorphic test devices (ATDs). However, there is a paucity of data regarding the neck loads generated during non-injurious situations for children. Six males and six females aged 8-11 years old were equipped with a validated head sensor package and upper neck loads and moments were calculated from measured head kinematics while performing a series of playground-type activities. The maximum forces were 686 N in compression, 177 N in tension, and 471 N in shear, the maximum moments were 18.2 N-m in flexion, 6.0 N-m in extension, 6.4 N-m in lateral bending, and 12.1 N-m in axial twist. Female subjects exhibited similar loads and moments to their male counterparts, but larger Nij values. The peak loads measured in this study are larger than or comparable to those undertaken with adult subjects participating in similar activities.

Over the past decade, there has been an increase in awareness and concern about the occurrence and long-term effects of concussions. Traumatic brain injury (TBI)-related emergency department (ED) visits associated with motor vehicle collisions, including patients with a diagnosis of concussion or mild TBI (mTBI), have increased while deaths and hospital admissions related to TBI have decreased. The diagnostic criteria for concussion have evolved and broadened, and based on current assessments and diagnostic imaging techniques, there are often no objective findings, yet a diagnosis of concussion may still be rendered. Clinical assessment of concussion may be based only on patient-reported symptoms and history, making it difficult to objectively relate the reported increase in TBI-related ED visits due to motor vehicle collisions to specific collision parameters.

Each year, over half of the world's 1.17 million fatalities resulting from traffic collisions are pedestrians (World Bank, 2008). Mitigation of such fatalities and serious injuries requires a thorough understanding of the common injury mechanisms that occur in pedestrian impacts. Studying the frequency of injury to each body region and how injury patterns are related may provide additional insight into pedestrian injury mechanisms, which could be used to develop additional prevention strategies. There is a wealth of information regarding pedestrian collisions within national databases that have not been extensively used to investigate these issues to date. This paper presents a review of selected databases that contain information regarding injuries to pedestrians who have been involved in a motor vehicle collision, including the strengths and weaknesses of each in performing this type of analysis.