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A Regenerative Life Support System (RLSS) is a system that establishes self-sustained material recycling and circulation within a space base on the Moon or Mars. This is a large-scale and complicated system comprising a lot of components such as humans, plants and material circulation system. A RLSS contains many factors with uncertainty, such as dynamics of plants and humans, and failure and performance deterioration of devices. In addition, a RLSS is a large-scale and complicated system extending gradually. An environment with uncertainty or a large-scale and complicated system may not be properly addressed by a centralized system. In particular, such a system cannot always gather accurate information in one center in a frequently shifting environment, thus appropriate processing may be difficult. Therefore, we tried autonomous decentralization of information or decision-making using a Multi-Agent System (MAS).