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Mathematical models which can aid in the design of monolithic oxidation catalyst systems are described. The chemistry math model allows prediction of tailpipe CO and HC emissions throughout the course of the Federal Test Procedure. Following a brief description of the model and its required inputs, several examples of model applications are presented. In these, the effects on emissions of several design variables are determined. The pressure drop model allows evaluation of system backpressure under steady flow conditions. Its use is illustrated by a parametric study of backpressure as a function of flow rate, substrate cell density and length.