A new, systematic, sensitivity based design process for weight reduction is presented. Traditionally, a trial and error method is used when a design fails to meet the weight and the design criteria, which often conflict. This old approach not only is time and cost consuming but also does not provide insight into structural behavior. This proposed process uses state-of-the-art technologies such as design sensitivity analysis, numerical optimization, graphical user interface, etc. It handles multi-discipline design criteria simultaneously and provides design engineers insight into structural responses for frequency, durability, and stiffness concerns and a means for systematic weight reduction and quality improvement. The new design process has been applied for the weight reduction of advanced truck frame designs. Results show that a significant weight savings has been achieved while all design criteria are met.