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Low-speed collisions between tractor-semitrailers and passenger vehicles may result in large areas of visible damage to the passenger vehicle, but often produce limited damage to the tractor-semitrailer. Despite this, such accidents may lead to assertions of serious injury to the tractor driver and/or sleeper compartment occupant. Research regarding the impact environment and resulting injury potential of the occupants during these types of impacts is limited. This research investigated driver and sleeper compartment occupant responses to relatively low-speed and low-acceleration impact events. Five crash tests involving impact between a tractor-semitrailer and a passenger car were conducted. The test vehicles were a van semitrailer pulled by a tractor and three identical mid-sized sedans. The occupants of the tractor included a human driver and an un-instrumented Hybrid III 50th-percentile-male anthropomorphic test device (ATD).