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A dynamic simulation of the ISS CDRA hardware was created using the Aspen Custom Modeler software platform. The dynamic model calculates the material and energy balances that describe the system properties. The model was calibrated by comparison to test data results from a flight-like CDRA at NASA Marshall Space Flight Center. While other FORTRAN models of the CDRA already exist, developing an ACM simulation is the first step towards creating a generic tool to simulate larger collections of life support hardware. The ACM tool should make it possible to be very flexible when rearranging these models to simulate possible configurations of the life support subsystems that could be used in the future, especially for advanced life support applications.