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The Waste and Hygiene Compartment will serve as the primary facility for metabolic waste management and personal hygiene on the United States segment of the International Space Station. The Compartment encloses the volume of two standard ISS racks and will be installed into Node 3 after launch inside a Multipurpose Logistics Module on the Space Shuttle. Long duration space flight requires a departure from the established hygiene and waste disposal practices employed on the Space Shuttle. This paper describes requirements and a conceptual design for the Waste and Hygiene Compartment that are both logistically practical and acceptable to the crew.