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Computational modeling is a potentially powerful tool to provide information about the mechanisms of traumatic brain injury. In order to ensure that the estimates calculated by these computer models provide the most useful information, it is essential that these models contain accurate central nervous system (CNS) tissue properties. Previous material property measurements lack strict control over crucial experimental parameters that may influence material properties and tail to examine any regional variation in the measured response. To address these issues, we measured the material response of two regions of the CNS, the brainstem and the cerebrum. Specifically, adult porcine tissue was subjected to high loading rate mechanical deformation using a custom designed oscillatory shear device. Complex shear moduli were calculated over a range of frequencies (20-200 Hz) at two engineering strain amplitudes (2.5%, and 5.0%).