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After several decades of human spaceflight, the community of space-faring nations has accumulated a diverse and sometimes harrowing history of toxicological events that have plagued human space endeavors almost from the very beginning. Some lessons have been learned in ground-based test beds and others were discovered the hard way - when human lives were at stake in space. From such lessons one can build a risk-management framework for toxicological events to minimize the probability of a harmful exposure, while recognizing that we cannot predict all possible events. Space toxicologists have learned that relatively harmless compounds can be converted by air revitalization systems into compounds that cause serious harm to the crew.

Lunar dust exposures occurred during the Apollo missions while the crew was in the lunar module on the moon's surface and especially when micro-gravity conditions were attained during rendezvous in lunar orbit. Crews reported that the dust was irritating to the eyes, and in some cases, respiratory symptoms were elicited. NASA's current vision for lunar exploration includes stays of 6 months on the lunar surface hence the health effects of periodic exposure to lunar dust in the habitat need to be assessed. NASA is performing this assessment with a series of in vitro and in vivo tests with authentic lunar dust. Our approach is to “calibrate” the intrinsic toxicity of lunar dust by comparison to a relatively low toxicity dust (TiO2) and a highly toxic dust (quartz) using intrapharyngeal instillation of the dusts to mice. A battery of indices of toxicity is assessed at various time points after the instillations.

NASA has unique requirements for the development and application of air quality standards for human space flight. Such standards must take into account the continuous nature of exposures, the possibility of increased susceptibility of crewmembers to the adverse effects of air pollutants because of the stresses of space flight, and the recognition that rescue options may be severely limited in remote habitats. NASA has worked with the National Research Council Committee on Toxicology (NRCCOT) since the early 1990s to set and document appropriate standards. The process has evolved through 2 rounds. The first was to set standards for the space station era, and the second was to set standards for longer stays in space and update the original space station standards. The update was to be driven by new toxicological data and by new methods of risk assessment for predicting safe levels from available data. The last phase of this effort has been completed.

Airborne dust, suspended inside a space vehicle or in future celestial habitats, can present a serious threat to crew health if it is not controlled. During some Apollo missions to the moon, lunar dust brought inside the capsule caused eye irritation and breathing difficulty to the crew when they launched from the moon and reacquired “microgravity.” During Shuttle flights reactive and toxic dusts such as lithium hydroxide have created a risk to crew health, and fine particles from combustion events can be especially worrisome. Under nominal spaceflight conditions, airborne dusts and particles tend to be larger than on earth because of the absence of gravity settling. Aboard the ISS, dusts are effectively managed by high efficiency filters, although floating dust in newly-arrived modules can be a nuisance.

A combustion products analyzer (CPA) was built for use on the Shuttle in response to several thermodegradation incidents during early flights. When the Toxicology Laboratory at Johnson Space Center (JSC) began to assess the air quality monitoring needs for the International Space Station (ISS), the CPA was the starting point for the design of a thermodegradation event monitor. The final product was significantly different from the CPA and was named the “compound specific analyzer-combustion products” (CSA-CP). One major change from the CPA was the replacement of the hydrogen fluoride sensor with an oxygen sensor. The focus of this paper will be the CSA-CP oxygen sensor’s ground testing, performance on ISS, and reduced pressure testing in response to a need on ISS.

NASA issued a Request For Information (RFI) to identify technologies that might be available to monitor a list of air pollutants in the ISS atmosphere. After NASA received responses to the RFI, an expert panel was assembled to hear presentations from 9 technology proponents. The goal of the panel was to identify technologies that might be suitable for replacement of the current Volatile Organics Analyzer (VOA) within several years. The panelists consisted of 8 experts in analytical chemistry without any links to NASA and 7 people with specific expertise because of their roles in NASA programs. Each technology was scored using a tool that enabled rating of many specific aspects of the technology on a 4-point system. The maturity of the technologies ranged from well-tested instrument packages that had been designed for space applications and were nearly ready for flight to technologies that were untested and speculative in nature.

There are many sources of air pollution that can threaten air quality during space missions. The International Space Station (ISS) is an extremely complex platform that depends on a multi-tiered strategy to control the risk of excessive air pollution. During the seven missions surveyed by this report, the ISS atmosphere was in a safe, steady-state condition; however, there were minor loads added as new modules were attached. There was a series of leaks of octafluoropropane, which is not directly toxic to humans, but did cause changes in air purification operations that disrupted the steady state condition. In addition, off-nominal regeneration of metal oxide canisters used during extravehicular activity caused a serious pollution incident.

The Toxicology Laboratory at Johnson Space Center (JSC) had provided the combustion products analyzer (CPA) since the early 1990s to monitor the spacecraft atmosphere in real time if a thermodegradation event occurred aboard the Shuttle. However, as the operation of the International Space Station (ISS) grew near, an improved CPA was sought that would include a carbon monoxide sensor that did not have a cross-sensitivity to hydrogen. The Compound Specific Analyzer-Combustion Products (CSA-CP) was developed for use on the International Space Station (ISS). The CSA-CP measures three hazardous gases, carbon monoxide, hydrogen cyanide, and hydrogen chloride, as well as oxygen. The levels of these compounds in the atmosphere following a thermodegradation event serve as markers to determine air quality. The first permanent ISS crew performed the CSA-CP checkout operations and collected baseline data shortly after arrival aboard the ISS in December 2000.

Space-faring crews must have safe breathing air throughout their missions to ensure adequate performance and good health. Toxicological assessment of air quality depends on the standards that define acceptable air quality, measurements of pollutant levels during the flight, and reports from the crew on their in-flight perceptions of air quality. Air samples from ISS flights 2A.2a, 2A.2b, 3A, and 4A were analyzed for trace pollutants. On average the air during each flight was safe for human respiration. However, there were reports from the crew that they experienced a headache when in certain areas, and strong odors were reported from specific locations of the ISS complex. Inspection of air samples in these locations suggested that several of the solvent-type pollutants (e.g. ethyl acetate, xylenes, and n-butanol) were present in concentrations that would cause a strong odor to be perceived by some individuals.

Spacecraft modules that are last purged with clean air several months before they are entered by humans on orbit require careful management. The crew must not be exposed to harmful concentrations of air pollutants when they first enter. The magnitude of the pollution the crew will encounter depends on the volume of the module, the length of time since the last clean-air purge or scrub, the inherent offgassing rate of the materials in the module, the interior temperature of the module while offgassing occurs, and the system leak rate. The time of the last module purge or scrub can be several months before crew entry, so it is essential that the offgassing rate within the module be measured over a suitable interval of time to estimate pollution levels with confidence. Air samples were taken from the STS-74 Russian Docking Module, the STS-79 Spacehab, and the ISS Node 1 prior to launch to predict pollution levels at crew first entry.

Experiences during the Shuttle and NASA/Mir programs illustrated the need for a real-time volatile organic analyzer (VOA) to assess the impact of air quality disruptions on the International Space Station (ISS). Toward this end, a joint development by the Toxicology Laboratory at Johnson Space Center and Graseby Dynamics (Watford, UK) produced a 1st generation VOA that has been delivered and is ready for the first 5 years of ISS operation. Criteria for the selection of the 1st generation VOA included minimizing the size, weight, and power consumption while maintaining analytical performance. Consequently, a VOA system based upon gas chromatography/ion mobility spectrometry (GC/IMS) was selected in the mid-90’s. A smaller, less resource-intensive device than the 1st generation VOA will be needed as NASA looks beyond ISS operations. During the past three years, efforts to reduce the size of ion mobility spectrometers have been pursued.

A volatile organic analyzer (VOA), developed by Graseby Dynamics, Ltd. under contract to the Johnson Space Center Toxicology Laboratory, is the core instrument for trace contaminant monitoring on the International Space Station (ISS). The VOA will allow trace amounts of target compounds to be analyzed in real time so that ISS air quality can be assessed in nominal and contingency situations. Recent events on Mir have underscored the need for real-time analysis of air quality so that the crew can respond promptly during off-nominal conditions. The VOA, which is based on gas chromatography/ion mobility spectrometry, is the first spacecraft instrument to be used for such a complex task. Consequently, a risk mitigation experiment (VOA/RME) was flown to assess the performance and engineering aspects of the VOA. This paper is a review of VOA/RME results from the STS-81 and STS-89 flights and their implications for the ISS VOA design and operations.

The complexity of the atmosphere aboard the International Space Station (ISS) will require a multifaceted monitoring strategy for both nominal and emergency conditions to protect the health and safety of the crew. Samples to be collected for air-quality assessment will include both archival sampling for ground analysis and on-board automatic analyses. Archival samples will be analyzed after return by standard gas chromatography/mass spectrometry; a separate formaldehyde analysis will be conducted as well. On-orbit analyses are planned for specific combustion products and for specific volatile organic compounds of toxicological significance. The air-lock will be monitored after EVAs to ensure that no propellants are introduced into the cabin atmosphere. Additional remote samples can be collected in sample bags from other ISS elements and brought to the Volatile Organic Analyzer (VOA) for analysis.

The monitoring of trace pollutants in spacecraft air is essential to protect the crew from harmful exposures. Monitoring requirements are focused on those sources of pollutants that pose the highest risk to crew health. Deciding which sources pose the greatest risk is done based on years of experience with the Space Shuttle, and more recently with the Russian Mir space station. Combustion of nonmetallic materials associated with electric circuits or heat-generating devices poses the greatest risk to crew health. Major leaks of fluids from systems or payloads also pose a significant risk. Other potential risks include accumulation of metabolites, entry of propellants, and excess offgassing, especially in modules that have been sealed for long periods.

Since the early years of the manned space program, NASA has developed and used exposure limits called Spacecraft Maximum Allowable Concentrations (SMACs) to help protect astronauts from airborne toxicants. Most of these SMACS are based on an exposure duration of 7 days, since this is the duration of a “typical” mission. A set of “contingency SMACs” is also being developed for scenarios involving brief (1-hour or 24- hour) exposures to relatively high levels of airborne toxicants from event-related “contingency” releases of contaminants. The emergency nature of contingency exposures dictates the use of different criteria for setting exposure limits. The NASA JSC Toxicology Group recently began a program to document the rationales used to set new SMACs and plans to review the older, 7-day SMACs. In cooperation with the National Research Council's Committee on Toxicology, a standard procedure has been developed for researching, setting, and documenting SMAC values.

As mission length and the number and complexity of payload experiments increase, so does the probability of thermodegradation contingencies (e.g. fire, chemical release and/or smoke from overheated components or burning materials), which could affect mission success. When a thermodegradation event occurs on board a spacecraft, potentially hazardous levels of toxic gases could be released into the internal atmosphere. Experiences on board the Space Shuttle have clearly demonstrated the possibility of small thermodegradation events occurring during even relatively short missions. This paper will describe the Combustion Products Analyzer (CPA), which is being developed under the direction of the Toxicology Laboratory at Johnson Space Center to provide necessary data on air quality in the Shuttle following a thermodegradation incident.