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Compression ignition internal combustion engines provide unmatched power density levels, making them suitable for numerous applications including heavy-duty freight trucks, marine shipping, and off-road construction vehicles. Fossil-derived diesel fuel has dominated the energy source for CI engines over the last century. To mitigate the dependency on fossil fuels and lessen anthropogenic carbon released into the atmosphere within the transportation sector, it is critical to establish a fuel source which is produced from renewable energy sources, all the while matching the high-power density demands of various applications. Dimethyl ether (DME) has been used in non-combustion applications for several decades and is an attractive fuel for CI engines because of its high reactivity, superior volatility to diesel, and low soot tendency. A range of feedstock sources can produce DME via the catalysis of syngas.