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Low- to moderate-speed motor vehicle collisions are common roadway occurrences that are generally associated with low rates of reported injury. While such complaints are generally infrequent, claims of injuries resulting from low- to moderate-speed motor vehicle collisions persist. A limited body of literature using quantitative techniques and full-scale crash tests is available to assess the injury potential associated with such collisions. Prior studies have analyzed occupant kinematics and kinetics as well as human injury risk in low- to moderate-speed collisions with older vehicle vintages but do not assess the effects of updated vehicle interior designs and occupant protection devices reflective of efforts to optimize occupant kinematics and reduce occupant loading and injury risk in more modern vehicles.