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Automotive manufacturers are concerned about the safety of its customers. Safety critical components like wheel hub are designed considering the severe loads generated from various customer usage patterns. Accelerated tests, which are derived from Real World Usage Patterns (RWUP), are conducted at vehicle level to ensure the wheel hub meet the durability targets. Load and strain measurement are done to understand the critical lateral loading undergone by the wheel hub. Measured data is synthesized to drive the duty cycle. Finite Element (FE) Analysis of Wheel end is performed at module level considering measured loads to capture the exact load path in physical test. Simulation results are compared with the measured strain for validating the FE analysis procedure. FE analysis was repeated for different wheel hub designs, combinations of different flange radius (R) and flange width (t), to understand the effect of the two critical dimensions on wheel hub durability.