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The elemental composition of food consumed by astronauts is well defined. The major elements carbon, hydrogen, oxygen, nitrogen and sulfur are taken up in large amounts and these are often associated with the organic fraction (carbohydrates, proteins, fats etc) of human tissue. On the other hand, a number of the elements are located in the extracellular fluids and can be accounted for in the liquid and solid waste fraction of humans. These elements fall into three major categories - cationic macroelements (e.g. Ca, K, Na, Mg and Si), anionic macroelements (e.g. P, S and Cl and17 essential microelements, (e.g. Fe, Mn, Cr, Co, Cu, Zn, Se and Sr). When provided in the recommended concentrations to an adult healthy human, these elements should not normally accumulate in humans and will eventually be excreted in the different human wastes.

The Research Animal Holding Facility (RAHF) is a spaceflight-qualified hardware system for housing adult rats. The Neurolab Space Shuttle mission, targeted for February 1998 on STS-89, will include neuroscience experiments involving nursing rat dams and neonates (newborn rats). Rat neonates have never been previously flown for spaceflight experimentation, and they present unique life support, science, and engineering challenges in the Spacelab microgravity environment. Modifications of the RAHF (with an associated comprehensive testing program, including spaceflight) are currently underway at NASA Ames Research Center (ARC), in order to add to the RAHF the capability of supporting nursing dams and neonates in preparation for Neurolab.