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Low-frequency vibration caused by road roughness while driving is transmitted to the human body through tires, suspension, and seats. Prolonged exposure of the human body to the vibratory environment will have an impact on ride comfort or even health issues. In order to investigate the vibration response of various segments of occupants while driving, a 15-DOF multi-body dynamic model depicting the shanks with feet, thighs, pelvis, torso with arms, and the head of occupants is established in the two-dimensional sagittal plane, which considers the contact between the occupant and the cushion, backrest headrest, and the vehicle floor simultaneously. The biodynamic parameters are obtained by fitting the published vibration experimental data based on an optimization algorithm. The previously proposed half-car model is incorporated into the human model to construct an integrated vehicle-human model for further ride comfort analysis.