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This paper presents a design process with data mining technique and advanced optimization strategy. The proposed design method provides insights in three aspects. First, data mining technique is employed for analysis to identify key factors of design variables. Second, relationship between multiple types of size and shape design variables and performance responses can be analyzed. Last but not least, design preference can be initialized based on data analysis to provide priori guidance for the starting design points of optimization algorithm. An exhaust system design problem which largely contributes to the improvement of vehicular Noise, Vibration and Harshness (NVH) performance is employed for the illustration of the process. Two types of design parameters, structural variable (gauge of component) and layout variable (hanger location), are considered in the studied case.