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Spine degeneration can lower injury tolerance and influence injury outcomes in vehicle crashes. To date, limited information exists on the effect of age and sex on thoracic spine 3-dimensional geometry. The purpose of this study is to quantify thoracic spinal column and canal geometry using selected geometrical measurement from a large sample of CT scans. More than 33,488 scans were obtained from the International Center for Automotive Medicine database at the University of Michigan under Institutional Review Board approval (HUM00041441). The sample consisted of CT scans obtained from 31,537 adult and 1,951 pediatric patients between the ages of 0 to 99 years old. Each scan was processed semi-automatically using custom algorithms written in MATLAB (The Math Works, Natick, MA). Five geometrical measurements were collected including: 1) maximum spinal curvature depth (D), 2) T1-to-T12 vertical height (H), 3) Kyphosis Index (KI), 4) kyphosis angle, and 5) spinal canal radius.

The purpose of this study was to use detailed medical information to evaluate thoracic injuries in elderly patients in real world frontal crashes. In this study, we used analytic morphomics to predict the effect of torso geometry on rib fracture, a major source of injury for the elderly. Analytic morphomics extracts body features from computed tomography (CT) scans of patients in a semi-automated fashion. Thoracic injuries were examined in front row occupants involved in frontal crashes from the International Center for Automotive Medicine (ICAM) database. Among these occupants, two age groups (age < 60 yr. [Nonelderly] and age ≥ 60 yr. [Elderly]) who suffered severe thoracic injury were analyzed. Regression analyses were conducted to investigate injury outcomes using variables for vehicle, demographics, and morphomics. Compared to the nonelderly group, the elderly group sustained more rib fractures.

Liver injuries can be significant in vehicle crashes. In this study, the liver anatomy was quantified in both adult and pediatric populations as a function of gender and age. Five anatomical liver measurements were determined using CT scans of 260 normal livers. These measurements include the area and volume, and the length, width, and girth of the liver (IRB HUM00041441). To characterize geometrical shape, an inscribed sphere and circumscribed ellipsoid were fitted on the measurements. In the pediatric population the liver area and volume continuously increased with age. When normalized by patient weight, volume measurements show a decrease in volume with age, suggesting that the liver occupies a smaller proportion of the body with age. In the adult population, liver measurements varied with gender. The superior and inferior locations of the liver were also recorded with respect to the spine. The lower portion was at the L3 in small children and at L2 as children approached puberty.