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This paper presents a system-level design and initial equivalent systems mass (ESM) analysis for a solid-phase thermophilic aerobic reactor (STAR) system prototype that is designed for a Mars surface mission. STAR is a biological solid waste treatment system that reduces solid waste, neutralizes pathogens, and produces a stabilized product amenable to nutrient reuse and water recovery in a closed life support system. The STAR system is designed for long-duration space missions or long-term remote planetary operations. A system-level design analysis for sizing a STAR process and the subsequent ESM based sensitivity analysis based on a 600-day Mars surface mission with a 6-person crew will be presented. Preliminary ESM sensitivity analysis identified that improving system energy conservation efficiency should be the focus of future research once the fundamental STAR process development has matured.