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At present, limited tools are available to model atmosphere control and supply systems simply, in order to allow quick design assessments based on analytical performances. In this context, the utilization of PC based ESACAP adapted as an Atmosphere Control and Supply (ACS) simulation tool is described. The analyses results shown in this paper refer to the activities of MPLM baseline re-definition carried out in accordance with the Space Station re-configuration. As a consequence, in several cases the described analyses reflect conservative assumptions and have been performed in a parametric way so as to take the uncertainties into account.