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This study focused on European NCAP activities of introducing a new head protection evaluation procedure, as proposed by BASt (Federal Highway Research Institute - GERMANY). Various kinds of E-bikes are available in the market, ranging from E-bikes that have a small motor to assist the rider’s pedal-power i.e., pedelecs to somewhat more powerful E-bikes which is similar to a moped-style scooter. This paper focused on identifying the factors influencing bicyclist head kinematics during bicycle vs. passenger vehicle (PV) collisions at the intersection. Two AM50 bicyclist FE models are developed using i) GHBMC Human Body Model (HBM) and ii) WorldSID (WS) side impact dummy. Head kinematics of bicyclists of pedal-assist E-bike and normal bike were compared using CAE simulation. It is found that the vehicle’s impact velocity, type of bicycle, the mass of E-bike and bicycle traveling speed will influence the head kinematics.