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Fatigue resulting from long-term driving can be classified into physical and mental fatigue. Physical fatigue seems to be mainly caused by driving posture. The purpose of this study is to develop a new driving posture for reduction of causal factors of physical fatigue, that is, biomechanical loads caused by the posture. In this paper, driving posture was optimized by subjective optimizations of seat contours and biomechanical analysis considering necessary conditions for driving operations and forward view. The new driving posture was tested by subjective evaluations and pelvic movement measurements. It was found that the new posture reduced physical fatigue dramatically.