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Advanced exhaust after-treatment technology is required for heavy-duty diesel vehicles to achieve stringent Euro VI emission standards. Diesel particulate filter (DPF) is the most efficient system that is used to trap the particulate matter (PM), and particulate number (PN) emissions form diesel engines. The after-treatment system used in this study is catalyzed DPF (CDPF) downstream of diesel oxidation catalyst (DOC) with secondary fuel injection. Additional fuel is injected upstream of DOC to enhance exothermal heat which is needed to raise the CDPF temperature during the active regeneration process. The objective of this research is to numerically investigate soot loading and active regeneration of a CDPF on a heavy-duty diesel engine. In order to improve the active regeneration performance of CDPF, several factors are investigated in the study such as the effect of catalytic in filter wall, soot distribution form along filter wall, and soot loads.