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For a planetary base, a reliable life support system including food and water supply, gas generation and waste management is a condition sine qua non. While for a short-term period the life support system may be an open loop, i.e. water, gases and food provided from the Earth, for long-term missions the system has to become more and more regenerative. Advanced life support systems with biological regenerative processes have been studied for many years and the processes within the different compartments are rather complete and known to a certain extent. The knowledge of the associated interfaces, the management of the input and output phases: liquid, solid, gas, between compartments, has been limited. Nowadays, it is well accepted that the management of these phases induces generic problems like capture, separation, transfer, mixing, and buffering. A first ESA study on these subjects started mid 2003.