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The integration of fuel cell systems as an independent energy source (Auxiliary Power Unit, APU) requires enhanced aircraft cooling architectures. New environmental control systems and systems with an increased cooling demand are investigated in various research projects. Cooling system architectures can be designed which benefit from similar requirements, e.g. by using the same cooling loops. Additionally, an increased cooling demand makes the investigation of alternative heat sinks necessary. For detailed system investigations simulation studies are used. A model library has been created in Dymola/Modelica containing the necessary component models to simulate cooling systems. The used modeling approaches and main model information are presented in this article. In order to understand the basic system behavior a Design of Experiment (DOE) is useful. If only two or three parameters are considered, simulation studies can be performed for each possible parameter combination.