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Worldwide scrutiny of the global warming impact of R-134a has presented the automotive industry with a pressing challenge to search for suitable alternative refrigerant(s). HFC-152a, referred to as R-152a in the air conditioning and refrigeration industry, is touted as an alternative [1, 2] to R-134a because of its lower global warming potential (GWP). R-152a is more environmentally benign than R-134a with GWP of 120 versus 1300. This paper is a follow up to the work on the potential applications of R-152a presented at the 2003 Vehicle Thermal Management Systems Conference (VTMS6) [3]. It documents continuing progress in applying R-152a to vehicle climate control systems. The paper compares R-152a cooling performance and energy performance to comparable R-134a system designs, including direct and indirect expansion systems. Also discussed are efforts to provide safe system operation with R-152a refrigerant.