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Aircraft systems are designed with reliability, safety and cost effectiveness in mind. The certification of the aircraft is based on tests and results of theoretical analyses that show the compliance with the FAR/JAR requirements. Monitoring for safety for in-service aircraft is an important, critical and extremely complex process. The ultimate objective is to assure that the safety level is equal to the original estimate or better. The manufacturer of the aircraft is particularly responsible for overall monitoring and assessment of all safety related events and corrective actions. Many different philosophies were adopted for this purpose. The safety monitoring and audit strategy is generally based on experience, engineering judgment, event analysis and numerical quantification by using probability theory and statistical tools. The aircraft sequential entry in the service and the aging of their components lead to the non-homogeneity of the fleet.