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NHTSA issued the FMVSS 226 ruling in 2011. It established test procedures to evaluate countermeasures that can minimize the likelihood of a complete or partial ejection of vehicle occupants through the side windows during rollover or side impact events. One of the countermeasures that may be used for compliance of this safety ruling is the Side Airbag Inflatable Curtain (SABIC). This paper discusses how three key phases of the optimization strategy in the Design for Six Sigma (DFSS), namely, Identify; Optimize and Verify (I_OV), were implemented in CAE to develop an optimized concept SABIC with respect to the FMVSS 226 test requirements. The simulated SABIC is intended for a generic SUV and potentially also for a generic Truck type vehicle. The improved performance included: minimization of the test results variability and the optimization of the ejection mitigation performance of the SABIC.