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This research investigates the variation of pedestrian stance in pedestrian-automobile impact using a validated multi-body vehicle and human model. Detailed vehicle models of a small family car and a sport utility vehicle (SUV) are developed and validated for impact with a 50th percentile human male anthropometric ellipsoid model, and different pedestrian stances (struck limb forward, feet together, and struck limb backward) are investigated. The models calculate the physical trajectory of the multi-body models including head and torso accelerations, as well as pelvic force loads. This study shows that lower limb orientation during a pedestrian-automobile impact plays a dominant role in upper body kinematics of the pedestrian. Specifically, stance has a substantial effect on the subsequent impacts of the head and thorax with the vehicle. The variation in stance can change the severity of an injury incurred during an impact by changing the impact region.