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Multidisciplinary Design Optimization (MDO) is of great significance in the lean design of vehicles. The present work is concerned with the objective of cross-functional optimization (i.e. MDO) of automotive body. For simplicity, the main goal adopted here is minimizing the weight of the body meeting NVH and crash safety targets. The stated goal can be achieved following either of two different ways: classic response surface method (RSM) and practical MDO methodology espoused recently. Even though RSM seems to be able to find a design point which satisfies the constraints, the problem is with the time associated with running such CAE algorithms that can provide a single optimal solution for multi-disciplinary areas such as NVH and crash safety.