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The formation of deposits in the fuel systems of heavy-duty engines, using drop-in fuels, has been reported in recent years. Drop-in fuels are of interest because they allow higher levels of alternative fuels to be blended with conventional fuels that are compatible with today’s engines. The precipitation of insolubles in the drop-in fuel can lead to clogging of fuel filters and internal injector deposits, resulting in increased fuel consumption and engine drivability problems. The possible mechanisms for the formation of the deposits in the fuel system are not yet fully understood. Several explanations such as operating conditions, fuel quality and contamination have been reported. To investigate injector deposit formation, several screening laboratory test methods have been developed to avoid the use of more costly and complex engine testing.