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Spacecraft hardware trade studies compare options primarily on mass while considering impacts to cost, risk, and schedule. Historically, other factors have been considered in these studies, such as reliability, technology readiness level (TRL), volume and crew time. In most cases, past trades compared two or more technologies across functional and TRL boundaries, which is an uneven comparison of the technologies. For example, low TRL technologies with low mass were traded directly against flight-proven hardware without consideration for requirements and the derived architecture. To provide for even comparisons of spacecraft hardware, trades need to consider functionality, mission constraints, integer vs. real number of flight hardware units, and mass growth allowances by TRL.

NASA's Constellation Program, which includes the mission objectives of establishing a permanently-manned lunar Outpost, and the exploration of Mars, poses new and unique challenges for human life support systems that will require solutions beyond the Shuttle and International Space Station state of the art systems. In particular, the requirement to support crews for extended durations at the lunar outpost with limited resource resupply capability will require closed-loop regenerative life support systems with minimal expendables. Planetary environmental conditions such as lunar dust and extreme temperatures, as well as the capability to support frequent and extended-duration Extra-vehicular Activity's (EVA's) will be particularly challenging.