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The proliferation and growth of microorganisms in the Internal Active Thermal Control System (IATCS) aboard the International Space Station (ISS) has been of significant concern since 2001. Initial testing and assessments of biocides to determine bacterial disinfection capability, material compatibility, stability (rate of oxidative degradation and identification of degradation products), solubility, application methodology, impact on coolant toxicity hazard level, and impact on environmental control and life support systems identified a prioritized list of acceptable biocidal agents including glutaraldehyde, ortho-phthalaldehyde (OPA), and methyl isothiazolone. Glutaraldehyde at greater than 25 ppm was eliminated due to NASA concerns with safety and toxicity and methyl isothiazolone was eliminated from further consideration due to ineffectiveness against biofilms and toxicity at higher concentrations.