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Computational Fluid Dynamics airflow models for the Waste and Hygiene Compartment (WHC) in the U.S. Laboratory module and Node 3 were developed and examined. The International Space Station (ISS) currently provides human waste collection and hygiene facilities in the Russian Segment Service Module (SM) which supports a three person crew. An additional set of Russian hardware, known as the system, is planned for the United States Operational Segment (USOS) to support expansion of the crew to six persons. Integration of the Russian system into the USOS incorporates direct Environmental Control and Life Support System (ECLSS) interfaces to allow more autonomous operation. A preliminary design concept was used to create a geometry model to evaluate the air interaction with the module cabin at varied locations and performance of the avionics fan placed in WHC. The Russian and the privacy protection bump-outs (Kabin) were included into the present modeling.