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Legislative challenges, changing customer needs and the opportunities opened-up by electrification are the major driving forces in today’s automotive industry. Fuel cell vehicles offer the potential for CO2 emission free mobility, especially attractive for heavy duty long-haul range application. The development of key components of fuel cell powered vehicles, namely the fuel cell stack itself as well as the related hydrogen/air supply and thermal management sub-systems, goes hand in hand with various challenges regarding performance, lifetime and safety. The proper layout and sizing of the stack and the related fuel and air supply system components, as well as the suitable dimensioning of the cooling system, are decisive for the overall system efficiency and achievable lifetime.