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During the last years extensive work has been done to design and develop the Closed-Loop Air Revitalization System ARES. The potential of ARES e.g. as part of the ISS ECLSS is to significantly reduce the water upload demand and to increase the safety of the crew by reducing dependence on re-supply flights. The design is adapted to the interfaces of the new base lined Russian MLM module as possible location for a future installation of ARES. Due to the lack of orbital support equipment and interfaces to a waste water bus, to a feed water supply line and due to the availability of only one single vent line it was necessary to make the ARES process water loop as independent as possible from the host vehicle. Another optimization effort was to match the CO2 desorption profile with the available hydrogen flow to achieve a sufficient water recovery performance, while meeting all related safety requirements, minimizing complexity and improving reliability.