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This study aims to investigate the relationship between the number of rib fractures and the thoracic deflection in side impact, and in particular its variability with respect to various loading configurations. The relevance of thoracic deflection as an injury criterion depends on the existence or not of this variability. Few studies were dedicated to this issue in the literature. First, a validation database was established, which covers different impact directions (frontal, lateral and oblique), different loading types (impactor, belt and airbag), and different injury levels (from the absence of, to presence of numerous ribs fractured). The HUMOS human body model was then modified and validated versus the database. Besides the typical validation in terms of global response, particular attention was paid to validate the model with respect to the ribcage strain profile, the occurrence of rib fractures and their locations.