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In this case study, a human factors engineering (HFE) analysis was carried out in the preliminary design phase of the Cupola. Cupola is a European Space Agency (ESA) module for manned space flights for the International Space Station (ISS) as part of a Barter Arrangement between ESA and the United States National Aeronautics and Space Administration (NASA). Manikin software was used early in the design process before the production of any flight hardware. The manikin analysis was supported by the use of hierarchical task analysis, a file exchange protocol and a relational database. This paper describes methodological aspects of the use of the supporting methods. Results show that hierarchical task analysis, a file exchange protocol and a relational database are prerequisites for successful extensive manikin analysis.