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Design optimization methods are widely used for weight reduction subjecting to multiple constraints in automotive industry. One of the major challenges is to search for the optimal design in an efficient manner. For complex design and optimization problems such as automotive applications, optimization algorithms work better if the initial searching points are within or close to feasible domains. In this paper, the k-means clustering algorithm is exploited to identify sets of reduced feasible domains from the original design space. Within the reduced feasible domains, the optimal design can be obtained efficiently. A mathematical example and a vehicle body structure design problem are used to demonstrate the effectiveness of the proposed method.