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This paper describes the transient simulation of a single-phase mechanically pumped fluid loop (MPFL) thermal control system, developed in the frame of the European Space Agency ARTES 8 (Advanced Research in Telecommunication Systems - Large Platform Program) program. MPFL is intended to cool a part of the payload on a high power telecommunication satellite. A transient simulation has been implemented using ESATAN/FHTS; hence the results have been correlated with the test results, obtained from full scale MPFL testing, using real on-orbit profiles. The most considerable parts of the activities described herein are simulation of the thermal control law, verification of control parameters during thermo-hydraulic testing and the subsequent correlation.