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The main objective of this study is to determine the damage tolerance and describe the damage mechanisms of the extended human knee when it is exposed to lateral impact loads in car-pedestrian accidents, particularly those that occur at a low velocity (20 km/h), and compare the results with those obtained at a high velocity (40 km/h). In-vitro experiments with human subjects were conducted where only the purest possible shearing deformation or the purest possible bending deformation affected the knee region at the time. Five experiments were performed in the shearing setup and another five in bending setup. The peak values of the shearing force and the bending moment related to the damage of knee ligaments and bone fractures were calculated at the knee joint level. Damages were assessed by dissecting the lower extremity. When the knee joint was exposed to the “purest possible shearing deformation”, the common initial damagemechanism was ligament damage related to ACL (60% of cases).