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It is generally considered that the material properties of foam are the most important factors in vehicle seat, which affect the human-seat interface pressure. Therefore, only the role of foam is usually considered when the finite element method is used to simulate the human-seat interface pressure. In this paper, the mechanical properties and the modeling method of commonly used seat cover material were studied. The models of the seat with and without cover were established respectively according to the real-vehicle seat geometric data, and the human-seat interface pressure was simulated after the seat and human model consisting of bones, soft tissue and skin were assembled. The simulation result was compared with the actual measurement results from test, which verified the accuracy of the simulation and the role of seat cover in the human-seat interface pressure simulation.