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In the last decades the development time of vehicles has been drastically reduced due to the application of advanced numerical and experimental methods. Specifications concerning durability and other functional attributes for every new model improve for every vehicle. In particular, for machines and components under variable multiaxial loading, fatigue evaluation is one of the most important steps in the design process. Appropriate material testing and simulation is the key to efficient life prediction. However, the life of automotive components, power plants and other high-temperature facilities depends mostly on thermo-mechanical fatigue (TMF). This is due to the normally variable service conditions, which contain the phases of startup, full load, partial load and shut-down.