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In this paper, tensile experiments were performed on the dorsal and ventral skin of rats, and the mechanical properties of the skin in these two sites were compared and analyzed. A three-factor experimental protocol of site (dorsal and ventral), strain rate (0.71s-1, 7.1×10-3s-1), and sampling orientation (0°, 45° and 90° relative to the spine) was established for tensile test using the L6(31×22) orthogonal table modified from the standard orthogonal table L4 (23). Uniaxial tensile experiments were performed on rat skin samples to calculate the stress-strain curve. The failure strain energy was selected as the index, and the sum of squared deviations of the factors to the index was calculated by analysis of variance (ANOVA), and the contributions of the factors to the failure strain energy were evaluated. The results showed that the site factor has the largest effect on the tensile strain energy with a contribution of 88.9% and a confidence level of 95%.

The hippocampus plays a crucial role in brain function and is one of the important areas of concern in closed head injury. Hippocampal injury is related to a variety of factors including the strength of mechanical load, animal age, and helmet material. To investigate the order of these factors on hippocampal injury, a three-factor, three-level experimental protocol was established using the L9(34) orthogonal table. A closed head injury experiment regarding impact strength (0.3MPa, 0.5MPa, 0.7MPa), rat age (eight- week-old, ten-week-old, twelve-week-old), and helmet material (steel, plastic, rubber) were achieved by striking the rat's head with a pneumatic-driven impactor. The number of hippocampal CA3 cells was used as an evaluation indicator. The contribution of factors to the indicators and the confidence level were obtained by analysis of variance.

Most of the skin injuries caused by traffic accidents, sports, falls, etc. are in the intermediate strain rate range (1-100s-1), and the injuries may occur at different sites, impact velocities, and orientations. To investigate the multifactorial mechanical properties of rat skin at intermediate strain rates, a three-factor, three-level experimental protocol was established using the standard orthogonal table L9(34), which includes site (upper dorsal, lower dorsal, and ventral side), strain rate (1s-1, 10s-1, and 100 s-1), and sampling orientation (0°, 45°, and 90° relative to the spine). Uniaxial tensile tests were performed on rat skin samples according to the protocol to obtain stress-stretch ratio curves. Failure strain energy was selected as the index, and the influence of each factor on these indexes, the differences between levels of each factor, and the influence of errors on the results were quantified by analysis of variance (ANOVA).