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Biological pre-treatment of early planetary/lunar base wastewater has been extensively studied because of its predicted ability to offer equivalent system mass (ESM) savings for long term space habitation. Numerous biological systems and reactor types have been developed and tested for treatment of the generally unique waste streams associated with space exploration. In general, all systems have been designed to reduce organic carbon (OC) and convert organic nitrogen (ON) to nitrate and/or nitrite (NOx -). Some systems have also included removal of the oxidized N in order to reduce overall oxygen consumption and produce additional N2 gas for cabin use. Removal of organic carbon will generally reduce biofouling as well as reduce energy and consumable cost for physiochemical processors.