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A two-dimensional mesoscopic approach has been developed to investigate the flow and soot loading in the micro-channels of diesel particulate filter. Soot particle size examined is in the range of 10 nm to 10 μm. The flow is solved by an incompressible lattice Boltzmann model and the transport of solid particle is described in a Lagrangian frame of reference by cell automation probabilistic model. The lattice Boltzmann-cell automation probabilistic model (LB-CA model) is validated with the results of previous studies. The heterogeneous porous wall of DPF is generated by quartet structure generation set (QSGS). The effects of porous wall on the pressure field and velocity field are investigated. The distribution and deposition of soot particles with different sizes in clean channels are simulated. The dynamic evolution of solid boundary in soot particle capture process is investigated and the effects of the deposited soot particles on flow field are evaluated.