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Based on equivalent static loads method (ESL), a nonlinear dynamic topology optimization is carried out to optimize an automotive body in white (BIW) subjected to representative legislative crash loads, including frontal impact, side barrier impact, roof crush and rear impact. To meet the crashworthiness performances, two evaluation indexes are defined to convert the practical engineering problems into mathematic optimization problems. The strain energy is treated as the stiffness evaluation index of the BIW and the relative displacement is employed as the compliance index of the components and parts.