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It is challenging to perform probabilistic analysis and design of large-scale structures because probabilistic analysis requires repeated finite element analyses of large models and each analysis is expensive. This paper presents a methodology for probabilistic analysis and reliability based design optimization of large scale structures that consists of two re-analysis methods; one for estimating the deterministic vibratory response and another for estimating the probability of the response exceeding a certain level. The deterministic re-analysis method can analyze efficiently large-scale finite element models consisting of tens or hundreds of thousand degrees of freedom and large numbers of design variables that vary in a wide range. The probabilistic re-analysis method calculates very efficiently the system reliability for many probability distributions of the design variables by performing a single Monte Carlo simulation.