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Ankle injuries continue to occur in motor vehicle collisions, particularly in female occupants. The causes of these injuries are sometimes unclear. Further understanding of ankle fracture tolerance and refinement of ankle injury prediction tools would help future injury prediction efforts. The goal of this study was to identify ankle injury types of interest and develop a test methodology to induce these injuries. Cases were examined from NHTSA’s Crash Injury Research Engineering Network (CIREN) database. 68 cases with distal tibia fracture were identified from CIREN years 2017+ (vehicle models years 2010+). The most common fractures were pilon fractures and malleolar fractures. Based on these results, a test methodology was developed to induce pilon and medial malleolar fractures in isolated cadaveric tibiae to quantify local fracture tolerance. Nineteen post-mortem human subject (PMHS) specimens (9 male and 10 female across a wide anthropometric range) were tested.