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Space exploration by humans requires maintenance of an adequate potable water supply. Biocide levels must therefore be kept within allowable limits to prevent bacterial growth without causing adverse effects on crew health. Likewise, contaminants such as heavy metals and toxic organic compounds must be held at or below acceptable limits. Currently, spacecraft water quality analyses are performed on samples collected on the International Space Station and returned to Earth. Several months, however, can pass between sample collection and analysis, which may compromise sample integrity due to degradation. These delays also inhibit implementation of real time correction scenarios. There is, therefore, a critical need for rapid, on-board methods for monitoring trace quantities of several analytes in spacecraft drinking water supplies.